LITTLE KNOWN FACTS ABOUT PKRRATING.

The activated enzyme then phosphorylates its key substrate, the translational initiation component eIF2α. The resulting translational arrest blocks viral replication. PKR belongs to the conserved household of 4 protein kinases (PKR, PERK, GCN2, HRI) that every one phosphorylate eIF2α in reaction to distinct stimuli12, triggering the built-in tens